Background in patients with acute ischemic stroke early treatment with thrombolytic agents is thought to permit reperfusion of ischemic neurons and to promote recovery of function. Thrombolytic therapy for acute ischemic stroke available evidence of thrombolysis in acute ischemic stroke comes from a series of recent trials conducted in patients with acute stroke and from a meta analysis published in the cochrane library. Thrombolytic therapy for acute ischemic stroke within 3h of symptom onset of highly select patients has been advocated by some groups since 1995 but trials have yielded inconsistent outcomes one recent trial demonstrated significant improvement when the therapeutic window was extended to 45h. Despite approval by the food and drug administration in 1996 intravenous thrombolytic therapy for acute ischemic stroke did not fully enter mainstream medical use for another 20 years in the meantime the ninds investigators published many articles over 10 years thoroughly describing the full study experience with the drug. Thrombolytic therapy for acute stroke the hidden dimension ossama mansour 1 2 and martin schumacher 2 author information cornerstone to the improvement of stroke therapy is the development of guidelines and education of physicians involved in the treatment of these patients but education is not enough as some neurologists have chosen not to participate in the care of stroke patients
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