Pancreatic neuroendocrine tumors pnet are rare tumors with a 1 100000 incidence and constitute approximately 2 to 10 of all pancreatic tumors nonfunctional pnets are difficult to detect at early stages since they have no symptoms except those detected accidentally during different diagnoses the majority of pnets are detected in the advanced stages with symptoms related to tumor size . Neuroendocrine tumors of the lung are a diverse group of diseases with distinct pathological molecular and clinical characteristics the most recent world health organization who classification identifies two types of high grade neuroendocrine carcinomas of the lung small cell lung carcinoma sclc and the less common large cell neuroendocrine carcinoma of the lung lcnec. Advances in the diagnosis and management of well differentiated and intermediate differentiated neuroendocrine tumors of the lung neuroendocrine tumors nets are a rare heterogeneous group of malignancies that arise from neuroendocrine cells throughout the body with the lungs and gi tract being the most common sites of origin. Abstract advances in pulmonary neuroendocrine tumor management by kjell oberg the spectrum of neuroendocrine tumors nets of the lung include on the one hand typical carcinoids and atypical carcinoids with a more indolent behavior and on the other hand the highly aggressive poorly differentiated large and small cell carcinomas. Guidelines for management of pnets are published by the north american neuroendocrine tumor society nanets 6 the enets 7 the american association of clinical endocrinologists and american college of endocrinology aace ace 5 and the national comprehensive cancer network nccn 53 each of these outline management from initial diagnosis through decision making for either surgical or medical management
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